Sunday, August 12, 2012

Based from what I have taken down during our discussion of our Pharmacology in Nursing class, here are vital information about anti-infective agents that I would like to share.

Anti-infective Agents are drugs that are desinged to act selectively on foreign organisms that have invaded and infected the body of a human host.

Antiobiotics treat bacterial infections.
Antivirals, antifungals and antiprotozoals treat infection caused by protozoa including malaria
Antihelmintics treat infections caused by worms.
Antineoplastics treat cancer disease caused by abnormal cells.

In 1920s the discover of the use of first drug to treat infection was discovered including penicillin.
Paul Ehrlich is a scientist to develop a synthetic chemical effective only against infection, causing the cells not human cells.
In 1935, sulfonamdes was discovered and introduced.

Those anti-infectives which interfere with the biosynthesis of the bacterial cell wall without interfering the host are the penicillin.

Sulfonamides, antimycobacterial and trimethoprim drugs are anti-infectives that prevents the growth and develepment of the bacteria.

Aminoglycosides, macrolides and chloramphenicol are anti-infectives that interfere with the steps involve in protein synthesis.

Fluoroquinolones are anti-infectives that interfere with the DNA synthesis in the cells.
Antifungals and antiprotozoals are anti-infectives that alter the permeability of the cell membrane, allow to leak out, causing the death of cells. 

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